Subcellular distribution and properties of kynurenine transaminase in rat liver.
نویسندگان
چکیده
Kynurenine transaminase activity in rat liver was found in both the mitochondrial and supernatant fractions. The mitochondrial and supernatant fractions contained (a) kynurenine-pyruvate transaminase, which showed a preference for pyruvate as amino acceptor and a pH optimum between 8.0 and 8.5, and (b) kynurenine-alpha-oxoglutarate transaminase, with a preference for alpha-oxoglutarate and a pH optimum between 6.0 and 6.5. Possible roles of these enzymes in tryptophan metabolism in the liver are discussed.
منابع مشابه
The kynurenine transaminase of rat kidney.
The conversion of kynurenine to kynurenic acid was observed in intact animals by Kotake (2) in 1931. This reaction was studied in vitro by Mason and Berg (3, 4), who observed that slices and homogenates of rat liver converted both tryptophan and kynurenine to kynurenic acid. Similar preparations from rat kidney did not convert tryptophan to kynurenine or kynurenic acid, but had a somewhat great...
متن کاملThe Kynurenine Transaminase of Rat Kidney*
The conversion of kynurenine to kynurenic acid was observed in intact animals by Kotake (2) in 1931. This reaction was studied in vitro by Mason and Berg (3, 4), who observed that slices and homogenates of rat liver converted both tryptophan and kynurenine to kynurenic acid. Similar preparations from rat kidney did not convert tryptophan to kynurenine or kynurenic acid, but had a somewhat great...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 143 2 شماره
صفحات -
تاریخ انتشار 1974